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Two independent studies have shown that early treatment with induced hypothermia protects from neurological sequels after out-of-hospital cardiac arrest (NEJM 2002 346(8): 549-556, 557-563). The importance of therapeutic hypothermia is supported by the advisory statement from the International Liaison Committee on Resuscitation (ILCOR), which was published recently (Resuscitation 57 (2003) 231-235, Circulation, 2003; 108:118-121).
  1. 1. Bernard et al. Treatment of comatose survivors of out of hospital cardiac arrest with induced hypothermia, N Engl J Med 2002; Vol 346, No 8: 557-563 
  2. 2. The Hypothermia after Cardiac Arrest study group. Mild therapeutic hypothermia to improve the outcome after cardiac arrest. N Engl J Med 2002; Vol 346, No 8: 549-556 
  3. 3. Bernard et al. Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest: a preliminary report. Resuscitation 56 (2003) 9-13 
  4. 4. Nolan et al. Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advanced Life Support Task Force of the International Liaison Committee on Resuscitation. Resuscitation 57 (2003) 231-235
     

First report from the Hypothermia Network:
Outcome, timing and adverse events in therapeutic hypothermia after out- of-hospital cardiac arrest
N. NIELSEN, J. HOVDENES, F. NILSSON, S. RUBERTSSON, P. STAMMET, K. SUNDE, F. VALSSON, M. WANSCHER and H. FRIBERG for the Hypothermia Network Acta Anaesthesiologica Scandinavica 2009; 53: 926?934